自然骨微管的三维仿生重建及两相流分析

Three-Dimensional Biomimetic Reconstruct and Two-Phase Flow Analysis of the Microtubules of Natural Bone

采用MATLAB、Mimics和PROE软件对观察骨组织切片获得的骨组织微观数据进行了三维重建和辅助设计，获得了骨微管的三维结构．通过对骨微管结构的细胞及细胞悬液的两相流分析，得出了结构中细胞浓度的分布．骨微管重建结构与根据能量守恒定律设计的骨微管结构比较的结果表明，骨微管结构的孔隙率较高，管道间距较均匀，比表面积更大，但由于该结构的细胞体积分数（1．635％～2．131％）不如按照能量守恒定律设计的骨微管内细胞体积分数（1．960％～2．050％）均匀，因此在设计人工骨支架时应优先考虑体外培养所需的流场环境，并在此基础上保证流道间距尽可能均匀、比表面积尽可能大，以确保材料降解的同步性和充分性．

The microstructure of bone tissue is investigated and analyzed to guide the design of internal microchannel architectures for scaffold. 3D reconstructions and the associated designs of the microstructure of bone tissue obtained via histologic sections are conducted with MATLAB, Mimics and PROE. Two-phase flow analysis in the bone microtubules is analyzed and the distribution of cell volume concentration is demonstrated. A comparision with the design based on en- ergy conservation law indicates the higher porosity, more identical channel spacing and larger specific surface of the proposed reconstructed bone, but whose uniformity of distribution of cell volume concentration （1. 635%-2. 131%） is less than the former（1. 960M-2.050%）. Thus, the flow field is considered primarily in scaffold design, then the possibly identical channel spacing and large specific area are taken into account to ensure complete material degradation.