回归正交设计分光光度法同时测定复方新诺明片中各组分含量

Simultaneous Determination of Two Components of Sulfamethoxazoli Composite by Regressive Orthogonal Designing Spectrophotometry

提出了复方新诺明（抗菌优）中磺胺甲基异恶唑（ＳＭＺ）和甲氧苄胺嘧啶（ＴＭＰ）回归正交设计分光光度法同时测定的新方法．该法利用ＴＭＰ在二氧六环中Ｅ２带的增色效应和紫移作用以及ＵＶ－２６５光度计的指令链功能，达到灵敏、准确、快速的目的．

A new method of regressive orthogonal designing spectrophotometry has been developed forthe simultaneous determination of sulfamethoxazoltlm (SMZ) and trimethoprim (TMP) containedin tabellae sulfamethoxazoli composite. The method makes use of the hyperchromic effect andblue shift effect of E2-band and the B-band of TMP,which reduces the oveslap between the TMPE2-band and the B-band of SMZ in 1, 4-dioxane. Its sensitivity,accuracy,and speed of determination are improved.