应用 ASGPR 相关指标结合 ICGR_(15)建立肝脏储备功能定量评估体系

Establishment of a system for quantitative evaluation of liver reservation function by combining relative factors of ASGPR with ICGR_(15)

目的应用肝脏去唾液酸糖蛋白受体(ASGPR)相关指标结合吲哚氰绿潴留率(ICGR_(15))综合建立肝脏储备功能的定量评估体系。方法测定大鼠模型肝脏功能残余量及其肝脏ASGPR 的 HH_(15)、LHL_(15)和 MRI 结合 ICGR_(15),建立一个以肝脏功能残余量(Y)为因变量,HH_(15)、LHL_(15)、MRI 和 ICGR_(15)为自变量的肝脏储备功能的综合定量评估体系。结果肝脏功能残余量 Y 值比 HH_(15)、LHL_(15)、MRI、ICGR_(15)等任何一个指标都敏感地反映出肝脏储备功能的变化。结论涵盖HH_(15)、LHL_(15)、MRI 及 ICGR_(15)等指标的回归方程 Y=2.56+33.188×MRI—44.844×HH_(15)+24.032×LHL_(15)—34.915×ICGR_(15)中的 Y 值是评估肝脏储备功能的敏感指标,能够对肝脏储备功能作出准确可行的定量评估。

Objective To establish a system for quantitative evaluation of liver reservation function by combining relative factors of ASGPR with ICGR15. Methods By analyzing rat liver asialoglycoprotein receptor indexes （HH15, LHL15 and MRI） and ICGR15 after hepatectomy of different pro portions, an integrative scale system for quantitative evaluation of liver reservation function was established. Results Remain of liver function （Y） was more sensitive than any of HH15, LHL15, MRI or ICGR15 when the liver reservation function changed. Conclusions The integrative coefficient Y in regression equation of Y=2. 56＋33. 188×MRI-44. 844 / HH15 ＋ 24. 032×LH15-34.915×ICGR15 including such indexes as HH15, LHL15, MRI and ICGR15 etc. is the most sensitive index for quantitative evaluation of liver reservation function. It liver reservation function in the model of liver cirrhosis can quantitatively and accurately evaluate the induced by carbon tetrachloride.