亲代出生体重对子代出生体重的影响

Correlation of birth weight across generations

目的探讨亲代出生体重对子代出生体重的影响及母亲官内发育不良的经历是否会影响子代宫内发育状况，为研究环境和遗传因素对出生体重的影响提供线索。方法首都儿科研究所采用回顾性队列研究，于1995-2001年以1948-1954年北京协和医院出生的“宫内发育与成人疾病”队列人群为基础。利用研究对象的出生记录和回顾性问卷调查资料，分析出生体重在亲代与子代之间的关联。结果在控制了母亲的产次、生育年龄以及配偶的身高体重等影响因素后，母亲的出生体重与其子代出生体重之间存在显著的正相关关系（r=0．38，P〈0．001），而父亲与子代之间在出生指标尚未表现出相关性；母亲为低出生体重（出生体重〈2500g），其子代中低出生体重发生的危险是对照组（亲代出生体重1〉3500g）的3倍多。结论母亲与子代在出生体重上存在明显正相关，母亲低出生体重可能会增加子代发生低出生体重的危险。

Objective To identify the impact that birth weights of parents exert on the birth weights of offsprings and to report some evidences of genetic and environmental influence on human birth weight. Methods The study was done from 1995 to 2001 retrospectively. The subjects were from the cohort of Intrauterine Programming and Adult Diseases （ totaling 975 cases ,494 males ,481 females ） ,who were born during 1948 - 1954 in Peking Union Hospital. The data was based on the clinical birth report from the hopital and self-report from subjects by questionnaire. The correlations of birth weight between parents and offsprings wem compared and analyzed. Results The influence from maternal parity, parturition age,and the height and weight of her spouse being controlled,there was a significant positive correlation [ r =0. 32, P 〈 0. 001 ）of birth weight between mothers＇ and their offsprings： The Odds Ratio of low birth weight in the first born child was 3.7 whose mother was low birth weight,with mother ＇ s birth weight being above 3500 g as reference. But there is no relationship of gestational age between mothers and offsprings. And the correlation of birth weight and gestational age between fathers and their offsprings was not observed. Conclusion To some extent, the mothers with low birth weight may impose the adverse effect of her poor intrauterine programming on her offsprings＇fetal growth.