孕妇肥胖对婴儿体格发育和瘦素质量浓度的影响

Influence of obese pregnancy on anthropometric parameters and leptin levels of offspring in infancy

目的探讨孕妇肥胖对婴儿体格发育和瘦素质量浓度的影响。方法武汉大学人民医院儿科于2002年1月至2003年6月选择肥胖孕妇和正常体重孕妇各80例,比较她们的子代在出生后及满1岁时的体重、身高和血清瘦素质量浓度;瘦素检测使用双抗体夹心ELISA法。结果符合检测数据统计条件的肥胖组为53例,正常组49例。(1)肥胖孕妇的瘦素质量浓度明显高于正常体重孕妇(P<0·01);(2)肥胖孕妇组子代出生体重和脐血瘦素质量浓度明显高于正常组(P<0·01);(3)肥胖孕妇组子代1岁时体重和血清瘦素质量浓度明显高于正常组子代(P<0·05)。结论孕妇肥胖对婴儿的体重和瘦素质量浓度有明显的影响,此影响对子代以后的生长发育和瘦素质量浓度是否继续存在还需要进一步的研究。

Objective To study influence of obese pregnancy on anthropometric parameters and leptin levels of offspring in infancy. Methods From Jun. 2002 to Jun. 2003, respectively separately 80 obese and normal pregnancy were selected in People＇s Hospital of Wuhan University, then we compared anthropometric parameters （high, weight） and leptin levels of their offspring in infancy. Leptin was examined by using a double-antibody with filling ELISA assay. Results （ 1 ） Serum leptin levels was significantly higher in obese pregnancy than in normal pregnancy（ P 〈 0.01 ） ;（2） Born weight and the cord blood leptin levels were significantly higher in offspring of obese pregnancy than of normal pregnancy（ P 〈0. 01 ） ; （ 3 ） Weight and serum leptin levels in one year were significantly higher in offspring of obese pregnancy than of normal pregnancy （ P 〈 0. 01 ）. Conclusion Obese pregnancy significantly affects weight and leptin levels of women offspring in infancy,and whether these effects affect anthropometric parameters and leptin levels after one year needs further researchs.