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新型火箭推进剂硝酸羟胺的毒性、毒理及其医学防护研究进展 被引量:3

Advances in study of toxicology of hydroxylammonium nitrate and medical protection against its poisoning
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摘要 硝酸羟胺(hydroxylammon ium n itrate,HAN)是新一代液体火箭推进剂的主要成分,具有能量高、弹头初速高、易贮存和易操作等特点;但HAN可通过多种途径导致人体中毒,且中毒程度与其浓度及剂量呈正相关;可对人体肺脏、肝脏和血液等系统造成损伤。本文介绍了HAN的理化性质,综述了HAN经皮肤、眼睛、气溶胶以及饮食等途径染毒后的毒性、毒理学及其医学防护研究进展。 Hydroxylammonium nitrate(HAN) is a main component of the new liquid rocket propellants. It has the charaeteristics of high power, relatively low toxicity and convenience. The major toxic effects of HAN can induce damages of lungs, liver, skin and blood. There is a positive correlation between the toxic effects and the dosage. In this paper, the physical and chemical properties and the toxic effects of HAN, and medical protection against its poisoning are reviewed.
出处 《军事医学科学院院刊》 CSCD 北大核心 2006年第1期95-97,共3页 Bulletin of the Academy of Military Medical Sciences
关键词 火箭推进剂 硝酸羟胺 毒理学 病理学 医学防护 rocket propellant hydroxylammonium nitrate toxicology pathology medical protection
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参考文献13

  • 1Savrun E,Schmidt E,Brand A.Novel catalysts for non-toxic monopropellants[R].Govt Reports Announcements,2003,103(13):86.
  • 2Kaplan DL,Riley PA,Emerson DJ,et al.Degradation of ammonium nitrate propellants in aqueous and soil systems[J].Environ Sci Technol,1984,18 (9):694-699.
  • 3Pennington JC,Price CB,Gunnison D,et al.Interactions of liquid propellant XM46 with soils[R].Govt Reports Announcements,1995,95(2):138.
  • 4Asaki A.Health hazard evaluation of liquid monopropellants.Phase 2.Effects of dermal administration of hydroxylammonium nitrate[R].Govt Reports Announcements,1982,82(25):5193.
  • 5Witt WM,Parker RM,Thurman JD,et al.LP1846 liquid gun propellant dermal toxicity study in male miniature handford swine[R].Govt Reports Announcements,1992,92(18):215.
  • 6Kemppainen BW,Terse P,Madhyastha MS,et al.In vitro assessment of in vivo damage to the barrier properties of pig skin caused by a complex mixture[J].J Toxicol Cutaneous Ocul Toxicol,1993,12(3):239-248.
  • 7Anon.Health hazard evaluation of liquid monopropellants.Phase 4.subchronic inhalation of hydroxylammonium nitrate[R].Govt Reports Announcements,1985,85(23):55.
  • 8Snodgrass HL.Health hazard evaluation of liquid monopropellants.Phase 5.comparative inhalation toxicities of LGP1776,LGP1845,and HAN (hydroxylammonium nitrate)[R].Govt Reports Announcements,1986,86(1):52.
  • 9Cooper JR,Caldwell DJ.Teratologic evaluation of liquid propellant (XM46) in the rat[J].J Appl Toxicol,1996,16(3):277-280.
  • 10Orner GA,Brown DF,Korte DW.Circulatory and hematological effects of liquid propellant 1846 following oral administration to rats[R].Govt Reports Announcements,1988,88(24):199.

二级参考文献12

  • 1杨春生 宋乃国.临床检验学[M].天津:天津科学技术出版社,1997.262-263.
  • 2[1]Taira J, Misik V, Riesz P. Nitric oxide formation from hydroxylamine by myoglobin and hydrogen peroxide [J]. Biochim Biophys Acta, 1997,1336(3) :502 - 508.
  • 3[2]Saul RL, Archer MC. Oxidation of ammonia and hydroxylamine to nitrate in the rat and in vitro[J]. Carcinogenesis, 1984,5(1):77-81.
  • 4Taira J, Misik V, Riesz P. Nitric oxide formation from hydroxylamine by myoglobin and hydrogen peroxide[ J]. Biochem Biophys Acta, 1997,1336(3) :502 - 508.
  • 5Saul RL, Archer MC. Oxidation of ammonia and hydroxylamine to nitrate in the rat and in vitro[J]. Carcinogenesis, 1984,5( 1 ) :77 - 81.
  • 6杨春生 宋乃国.临床检验学[M].天津:天津科学技术出版社,1997.152-323.
  • 7Taira J, Misik V, Riesz P.Nitrie oxide formation from hydroxylamine by myoglobin and hydrogen peroxide[ J]. Biochem Biophys Acta, 1997,1336(3) :502 - 508.
  • 8Saul RL, Archer MC. Oxidation of ammonia and hydroxylamine to nitrate in the mt and in vitro[J]. Carcinogenesis, 1984,5(1) :77 - 81.
  • 9史霄燕.茶多酚的抗氧化作用及机制[J].国外医学(药学分册),1998,25(4):196-199. 被引量:31
  • 10岳茂兴,杨鹤鸣,李建忠,徐世全,杨志焕,王正国,夏亚东,王德文,彭瑞云.冲击波和液体火箭推进剂中毒致冲毒复合伤大鼠实验模型的建立[J].中华航空航天医学杂志,2001,12(1):31-34. 被引量:26

共引文献4

同被引文献25

  • 1郑燕华,邹德威,冯凯,崔彦,张铭,许洋,李宁,张建中.蛋白芯片技术筛选肝癌血清标志蛋白的初步研究[J].中华检验医学杂志,2005,28(6):628-631. 被引量:26
  • 2陈建魁,王德文,彭瑞云,王水明,高亚兵,宋世平,李玉荣,尹秀云,胡文祥.硝酸羟胺对大鼠血液系统毒性作用的实验研究[J].中国卫生检验杂志,2006,16(6):741-743. 被引量:3
  • 3李建忠,冯凯,岳茂兴,刘志国,郑燕华,化楠,李轶.四氧化二氮致伤小鼠血清标志分子的实验研究[J].中华急诊医学杂志,2007,16(5):467-469. 被引量:4
  • 4安辉,杨录军,周燕虹,刘晋袆,刘胜学,杨桓,曹佳.硝酸羟胺亚慢性染毒对大鼠血液系统的影响[J].卫生研究,2007,36(4):505-507. 被引量:1
  • 5Sawun E, Schmidt E, Brand A. Novel catalysts for non -toxic monopropellants [ J ]. Govt Reports Announcements,2003,103 ( 13 ) :86.
  • 6Kinkead ER, Wolfe RE, Salins SA, et al. General toxicity and reproductive screen of liquid propellant XM46 administered in the drinking water of Sprague - Dawley rats[ J ]. Toxicol Ind Health, 1995, 11 ( 2 ) : 199 -215.
  • 7Yang R, Ma H, Thomas SM, et al. hnmunocytochemical analysis of syntaxin - 1 in rat circumvallate taste buds[ J ]. J Comp Neurol,2007, 502(6) :883 -893.
  • 8Gong Y, Xi GH, Keep RF, et al. Aging enhances intracerebral hemorrhage- induced brain injury in rats[ J ]. Aeta Neurochir Suppl, 2005, 95 : 425 - 427.
  • 9Yi JH, Hazell AS. N - acetylcysteine attenuates early induction of heme oxygenase - 1 following traumatic brain injury. [ J ]. Brain Res, 2005, 1033(1): 13-19.
  • 10Chang EF, Claus CP, Vreman HJ, et al. Heme regulation in traumatic brain injury : relevance to the adult and developing brain [ J ]. J Cereb Blood Flow Metab, 2005, 25( 11 ) : 1401 - 1417.

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