3-异烷氧基噻吩的合成

Synthesis of 3-Isoalkoxythiophene

以CuBr为催化剂，NMP为溶剂，在110℃下，3-溴噻吩与过量的甲醇钠反应2．5h生成3．甲氧基噻吩，产率为82％。再以无水NaHSO4为催化剂，在108—115℃下，3-甲氧基噻吩分别与异丁醇、异戊醇、异辛醇发生取代反应合成了3-（2-甲基丙氧基）噻吩、3-（3-甲基丁氧基）噻吩、3-（2-乙基己氧基）噻吩，反应时间分别为：3．3．5、4h，收率分别为72％、67％、63％。这些化合物结构都通过IR、^1HNMR和MS进行了表征，并对其进行了初步香味评价，结果表明，它们都具有基本肉香味的特征。

With cuprous bromide as catalyst and N-methylpyrrolidone （NMP） as solvent, 3- bromothiophene reacted with surplus sodium methoxide at 110 ℃ for 2.5 h to form 3-methoxythiophene in 82% yield. Then 3-（ 2-methylpropoxy ） thiophene, 3-（ 3-methylbutoxy ） thiophene and 3-（ 2- ethylhexoxy ） thiophene were respectively synthesized through substitution reaction of 3- methoxythiophene with isobutanol,isopentanol and isooctanol using sodium bisulfate as catalyst at 108 -115 ℃. The reaction times were 3,3.5 and 4 h and the yields were 72%,67% and 63% respectively. The products were confirmed by IR, ^1HNMR and MS. Their flavour was evaluated and it is shown that they all have basic meat flavour.