摘要
以CuBr为催化剂,NMP为溶剂,在110℃下,3-溴噻吩与过量的甲醇钠反应2.5h生成3.甲氧基噻吩,产率为82%。再以无水NaHSO4为催化剂,在108—115℃下,3-甲氧基噻吩分别与异丁醇、异戊醇、异辛醇发生取代反应合成了3-(2-甲基丙氧基)噻吩、3-(3-甲基丁氧基)噻吩、3-(2-乙基己氧基)噻吩,反应时间分别为:3.3.5、4h,收率分别为72%、67%、63%。这些化合物结构都通过IR、^1HNMR和MS进行了表征,并对其进行了初步香味评价,结果表明,它们都具有基本肉香味的特征。
With cuprous bromide as catalyst and N-methylpyrrolidone (NMP) as solvent, 3- bromothiophene reacted with surplus sodium methoxide at 110 ℃ for 2.5 h to form 3-methoxythiophene in 82% yield. Then 3-( 2-methylpropoxy ) thiophene, 3-( 3-methylbutoxy ) thiophene and 3-( 2- ethylhexoxy ) thiophene were respectively synthesized through substitution reaction of 3- methoxythiophene with isobutanol,isopentanol and isooctanol using sodium bisulfate as catalyst at 108 -115 ℃. The reaction times were 3,3.5 and 4 h and the yields were 72%,67% and 63% respectively. The products were confirmed by IR, ^1HNMR and MS. Their flavour was evaluated and it is shown that they all have basic meat flavour.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2006年第3期282-284,共3页
Fine Chemicals
基金
国家自然科学基金资助项目(20376003)~~