血液病合并肺曲霉菌感染临床分析

Invasive Pulmonary Aspergillosis in Hemopathy Patients: Its Diagnosis and Treatment

目的 了解血液病合并肺曲霉菌感染的情况，分析和探讨其临床特点、治疗方法及其预后。方法 回顾性分析2004年7月～2005年6月，我院收治的155例血液系统疾病患者中，合并肺曲霉菌感染的资料。结果 155例中，有3例发生肺曲霉菌感染，治愈1例，死亡2例。结论 过度免疫抑制是导致肺曲霉菌感染的重要因素；早期使用两性霉素B仍是治疗肺曲霉菌感染的有效药物；为降低两性霉素B的毒副作用，治疗方法上宜个体化，从小剂量开始，逐渐增加剂量，达有效剂量后维持2～3周，再用伊曲康唑巩固治疗2～3周。

OBJECTIVE To assess the clinical characters, diagnosis and treatment of invasive pulmonary aspergillosis in hemopathy patients. METHODS The hospitalized patients with hemopathy from Jul 2004 to Jun 2005 was retrospectivly analyzed. RESULTS Among 155 hemopathy cases, 3 cases developed invasive pulmonary aspergillosis, from them 2 died and 1 cured. CONCLUSIONS Overimmnosuppression is one of the main risk factors for invasivc pulmonary aspergillosis. Amphotericin B is still the best choice for the treatment of aspergillosis and its gradual, low concentration administration can ease the side effects.