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新的小分子活性肽intermedin/adrenomedullin-2 被引量：3

A new small molecular active peptide intermedin/adrenomedullin-2
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摘要 Interm ed in(IMD)/adrenom edu llin-2(ADM2)是最近克隆出来的降钙素基因相关肽(CGRP)超家族成员,其结构类似于CGRP、肾上腺髓质素,通过降钙素受体样受体/受体活性修饰蛋白起作用。IMD/ADM2是一种内源性心脏-肾脏保护因子,作为循环激素和旁/自分泌因子在多种组织中发挥广泛生物学功能,具有降低血压、扩张冠脉、抗心脏缺血/再灌注损伤、调节水和电解质平衡、调节垂体激素分泌等生物学效应。 Intermedin （IMD）/adrenomedullin-2 （ADM2） was recently cloned from mammals as a member of the calcitonin （CT）/CT gene-related peptide （CGRP） superfamily. They are structurally related to each other. IMD is an endogenous cardio-renal-protective substance through the calcitonin receptor-like receptor/receptor-activity-modifying- proteins（CRLR/RAMPs） system. It may exert multiple biological effects as a new paracrine/autocrine factor and circulating hormone on lowing blood pressure, dilating coronary artery, protecting ischemia/reperfusion-injuried heart, regulating fluid and electrolyte balance and acting as a pituitary paracrine factor regulating prolactin release.
作者 贾闪闪 吴小脉 龚永生
机构地区 温州医学院肺心病研究室
出处 《国际病理科学与临床杂志》 CAS 2006年第1期39-42,共4页 Journal of International Pathology and Clinical Medicine
基金 浙江省卫生厅资助项目(2005B126) 温州市科委资助项目(Y2004A115)
关键词 intemledin/adrenomedullin-2 降钙素基因相关肽 功能 intermedin/adrenomedullin-2 calcitonin-gene-related peptide function
分类号 R341 [医药卫生—基础医学]
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参考文献16

  • 1Roh J, Chang CL, Bhalla A, et al. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity modifying protein receptor complexes [ J ]. Biol Chem ,2004,279 ( 8 ) : 7264-7274.
  • 2Takei Y, Inoue K, Ogoshi M, et al. Identieation of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator[ J ]. FEBS Lett, 2004,556( 1-3 ) :53-58.
  • 3Katafuchi K, Hamano K, Kikumoto K, et al. Identification of second and third calcitonin receptor-stimulating peptides in porcine brain[ J]. Biochem Biophys Res Commun, 2003,308(3 ) :445-451.
  • 4Katafuchi T, Kikumoto K, Hamano K, et al. Caleitonin receptor-stimulating peptide, a new member of the caleitonin gene-related peptide family-its isolation from porcine brain, structure, tissue distribution, and biological activity [ J ]. Biol Chem, 2003,278 ( 14 ) :12046-12054.
  • 5Poyner DR, Sexton PM, Marshall I, et al. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors [ J ]. Pharmacol Rev,2002,54 ( 2 ) :233 -246.
  • 6Wimalawansa SJ. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide supeffamily [J].Critical Rev Neurobiol, 1997,11 ( 2-3 ) : 167-239.
  • 7Yallampalli C, Chauhan M, Thota CS, et al. Calcitonin gene-related peptide and its emerging receptor heterogeneity [ J ]. Trends Endocrinol Metab ,2002,13 ( 6 ) : 263 -269.
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同被引文献17

  • 1贾月霞,李桂忠,杨靖辉,潘春水,耿彬,张靓,唐朝枢,齐永芬.急性心力衰竭大鼠心肌intermedin受体的变化[J].宁夏医学院学报,2005,27(5):337-339. 被引量：6
  • 2谢晓繁,贾赤宇,付小兵,刘虎仙.成体表皮干细胞的分离培养与鉴定[J].中国危重病急救医学,2006,18(1):46-48. 被引量：10
  • 3龚永生,范小芳,吴小脉,胡良冈,唐朝枢,庞永政,齐永芬.Intermedin／adrenomedullin 2及其受体在慢性低氧性肺动脉高压大鼠右心室的表达变化[J].生理学报,2007,59(2):210-214. 被引量：17
  • 4[2]LiA,Simmons PJ,Kaur P.Indentification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype.Prec Natl Acad Sci USA,1998,95:3902-3907.
  • 5[3]Kaur P,Li A.Adhesive properties of human basal epidermal cells:an analysis of keratinocyte stem cells,transit amplifying cells,and postmitotie differentiating cells.J Invest Dermatol,2000,114:413-420.
  • 6[5]Takei Y,Inoue K,Ogoshi M,et al.Identification of novel adrenomedullin in mammals:a potent cardiovascular and renal regulator.FEBS Lett,2004,556(123):53-58.
  • 7[9]Roh J,Chang CL,Bhalla A,et al.Imennedin is a calcitonin/calcitonin gene related peptide family peptide acting through the calcitonin receptor like receptor/receptor activity moditying protein receptor complexes.J Bid Chem,2004,279(8):7264-7274.
  • 8中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南.中华哮喘杂志,2008,:126-128.
  • 9Takei Y, Inoue K, Ogoshi M, et al. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator[J]. FEBS Lett, 2004, 556(1-3):53-58.
  • 10Roh J, Chang CL, Bhalla A, et al. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modi- fying protein receptor complexes[J]. J Biol Chem,2004, 279(8):7264-7274.

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国际病理科学与临床杂志
2006年 第1期

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