神经调节因子及其信号转导机制

Neuregulins and their signal transduction mechanism

神经调节因子(NRG)是一个由4种基因编码的多肽家族,包含4种同源异构体NRG-1,2,3和4,其功能性受体是由ErbB酪氨酸激酶受体组成,属于跨膜酪氨酸激酶的表皮生长因子受体家族成员,包括ErbB2/HER2/neu,ErbB3/HERS和ErbB4/HER4。NRG通过诱导ErbB受体构象变化,使ErbB蛋白形成二聚体,继而激活酪氨酸激酶,引起C-末端的自身酪氨酸磷酸化和反式酪氨酸磷酸化,而发挥其生物学作用。

Neuregulins is a family of polypeptides encoded by 4 kinds of genes, including 4 homology isomers： NRG-1,2 ,3 and 4. Their functional receptors are ErbB tyrosine kinase receptors, known as transmembrane tyrosine kinase of epidermal growth factor receptor（EGFR） family members, including ErbB2/HER2/neu, ErbB3/HERS and ErbB4/HER4. NRG turns ErbB protein into dimer by inducing their conformation change. Then the dimer activates tyrosine kinase, leading to C-terminal self-tyrosine phosphorylation and antiform tyrosine phosphorylation, and educes its biology effect.