葡萄胎β-HCG含量与临床病理关系的研究

STUDIES ON THE β-HCG AND CLINICAL PATHOLOGY OF HYDATIDIFORM MOLE

本文应用免疫组织化学和图象分析方法,对74例葡萄胎的滋养细胞增生类型、β-HCG量和恶变率的关系进行研究。发现:1.合体滋养细胞增生为主型恶变率低于中间-细胞滋养细胞为主型;2.合体滋养细胞内β-UCG含量高,其恶变率低;3.滋养细胞增生程度与恶变率无明显关系。因此,我们认为病理检查、滋养细胞β-HCG含量对推测葡萄胎的预后有一定价值。

The relationship between the trophoblast-predominant type, β-HCG content, and malignant change rate in 74 cases of hydatidiform mole was studicd using immunohistochemistry and micro -spectroscopic image analysis methods. It was found that ( 1 ) malignant change rate in the syncytiotrophoblast-predominant type was lower that in the intermediate-cytotrophoblast predominant type; ( 2) in case syncytiotrophoblasts with a higher β-HCG content, the rate of malignant change of hydatidiform mole was decreased; (3) the relationship between the degree of tro-phoblastic proliferation and malignant change rate did not reach statistical significance. Our findings suggest that pathologic examination and β-HCG assay of trophoblast may be of help in predicting the prognosis of hydatidiform mole.