CA125、CA199、AFP水平与肝硬化腹水的关系探讨

Discussion of relationship between levels of CA125,CA199 and AFP and cirrhosis ascites

目的探讨肝硬化患者CA125、CA199、AFP与腹水的关系。方法用放射免疫法检测肝硬化患者217例和健康对照组50例,血清CA125、CA199、AFP水平,92例患者同时检测腹水CA125、CA199、AFP水平。结果肝硬化患者血清CA125显著高于正常对照组,并随肝硬化程度加重而进行性增加。伴有腹水患者血清CA125水平明显提高,与同一Child分级的无腹水患者相比有统计学意义。而且随着腹水量的增多,其血清CA125水平也呈逐渐升高趋势。CA199、AFP在肝硬化患者中轻度升高,但与肝硬化程度、腹水量无明显相关性。结论血清CA125水平对衡量肝硬化患者的预后、腹水量有一定的参考价值。CA199、AFP在肝硬化患者中轻度升高,但与腹水量无明显相关。

Objective It is to discuss the relationship between the levels of CA125, CA199 and AFP of cirrhosis patients and ascites. Methods The levels of CA125, CA199 and AFP in serum of 217 cirrhosis patients and 50 healthy people were detected with radioimmunoassay. The levels of CA125, CA199 and AFP in ascites of 92 cases were detected at the same time. Results The CA125 levels in serum of cirrhosis patients were significantly higher than that of healthy control group, and were added by the worsened of cirrhosis. The levels of CA125 in serum of ascites patients were obviously raised, and compared with the same child classification without ascites patients, it had statistics value. With the addition of ascites quantity, the levels of CA125 in serum were upward trend. The levels of CA199 and AFP in cirrhosis patients rose slightly, but it wasn＇t clearly correlation with cirrhosis degree and ascites quantity. Conclusion The levels of CA125 in serum will be definitely consulting value in weighing the prognosis of cirrhosis patients and the ascites quantity. The levels of CA199 and AFP in cirrhosis patients rose slightly, but it wasn＇t clearly correlation with ascites quantity.