肺螨病的病理观察

PATHOLOGICAL OBSERVATION OF EXPERIMENTAL PULMONARY ACARIASIS

本文报道螨类接种豚鼠气管引起的肺部病变,并对5种常见螨类的致病性进行比较。发现螨类接种后6天豚鼠肺部已形成典型的结节性病灶。结节圆锥形淡黄色,直径1～5mm之间。镜下表现为细支气管炎和细支气管周围炎,肺实质内有明显的异物肉芽肿形成,炎症在螨类接种豚鼠20天时,肺部嗜酸粒细胞浸润不明显,但30或40天时则出现明显的嗜酸细胞浸润,细支气管周围小动脉受到损害,部分小动脉内可见到螨体残骸。5种常见螨炎接种于5组豚鼠可引起大致相同的病变。从而证明豚鼠可作为动物模型以供肺螨病的研究,同时也证明5种常见贮藏螨具有相同的致病性。

Typical nodular foci developed in the lungs of guinea-pigs six days after mites were injected into the tracheas. The foxi occurred in all the parts of the lobes, which were found to be yellow in fresh tissues and arranged from one to five milimeters in diameter. The pathological changes were associated mainly with bronchiol and peribronchiol lesions. The eosinophile infiltration was not observed in the lungs 20 days after the injection, but the eosinophile infiltration was obvious 30 days later. Multiple multinucleate giant cells grew and there was a striking formation of foreign body granuloma with the involvement of blood vessels. The parasitic mites were usually found in association with some arteriol. It has been demonstrated that guinea-pigs may serve as the animal model for the study of pulmonary acariasis and the 5 common species of stored mites possess the same pathogenesis.