冠心病患者血液脂质过氧化产物与纤溶活性的关系

Relationsmps between lipid peroxidation and fibrinolytic activity in coronary heart disease

作者测定了１４例急性心肌梗塞（ＡＭＩ）、１８例不稳定性心绞痛（ＵＡ）、２０例稳定性心绞痛（ＳＡ）及２０例正常人的血液中脂质过氧化代谢产物丙二醛（ＭＤＡ）与组织型纤溶酶原激活剂（ｔ－ＰＡ）、纤溶酶原激活剂抑制物（ＰＡＩ－１）活性及纤维蛋白活化肽（Ｂ＿(β１－４２)）的含量，ＡＭＩ急性期及ＵＡ发作时血浆ＭＤＡ含量分别增加至５．０２±１．１８ｎｍｏｌ／ｍｌＰ＜０．０１，４．６７±１．２３μｍｏｌ／ＬＰ＜０．０１．ＰＡＩ－１活性分别增高至９０７７±１８６２Ａｕ／ＬＰ＜０．０１，８１２２±１４３７Ａｕ／ＬＰ＜０．０１．ｔ－ＰＡ活性分别降至４５７±２１２Ｉｕ／ＬＰ＜０．０１，５８２±２７６Ｉｕ／ＬＰ＜０．０１，Ｂ＿(β１－４２)含量则分别降至２．０４±１．２２ｎｍｏｌ／ＬＰ＜０．０１，３．４８±１．３２ｎｍｏｌ／ＬＰ＜０，０１，ＭＤＡ与ＰＡＩ－１呈正相关（ｒ＝０．７７４２Ｐ＜０．０１，ｒ＝０．６３１６Ｐ＜０．０１）．而与ｔ－ＰＡ及Ｂ＿(β１－４２)呈负相关（ｒ＝－０．６４６５Ｐ＜０．０１，ｒ＝－０．６０２８Ｐ＜０．０１，ｒ＝－０．６７５４Ｐ＜０．０１，ｒ＝－０．５８２８Ｐ＜０．０５）．提示自由基介导的脂质过氧化增加可导致纤溶?

The blood plasma malondialdehyde(MDA),tissue-type plasminogen activator(t-PA),plasmino-gen activator inhibitor(PAI-1)and fibrinopeptide B_(β1 42) were measured in 14 patients with acute myocardiac infarction,18 patients with unstable angina(UA),20 patients with stable angina(SA),and 20 healthy per-sons,The MDA contents in blood plasma were increased to 5.02±1.18 μmol/L P<0.01 and 4.67±1.23 μmol/L P<0.01 respectively at the onset of AMI and UA. The activities of PAI-1 were increased to 9077±1862 Au/LP<0.01 and 8122±1437 Au/LP<0.01 respectively,The activities of t-PA were reduced to 457±212 Iu/L P<0.01 and 582±276 Iu/L P<0.01 respectively.The contents of Bβ1 42 were reduced to 2.04±1.22 nmol/LP<0.01 and 3.48±1.32 nmol/L P<0.01 respectively,There was a positive correlation be-tween MDA and PAI-1(r=0.7742 P<0.01,r=0.6316 P<0.01)in AMl and UA groups. A negative cor-relation existed between MDA and t-PA and MDA with B_(β1 42)(r=-0.6465 P<0.01,r=-0.6028 P<0.01,r=-0.6754 P<0.01,r=-0.5828 P<0.05)in AMI and UA groups,It suggested that lipid peroxi-dation and the increase of the free radical can lower fibrinolysis activity,and the forming of the hypercoagula-ble state of theHood may result in coronary artery thrombosis.