速尿在代谢性酸中毒脑脊液酸碱调节中的作用

Effects of furosemide on cerebrospinal fluid acid-base regulation in a-cute metabolic acidosis

作者复制犬低碳酸血性代谢性酸中毒动物模型，动态观察动脉血和脑脊液（ＣＳＦ）的酸碱变量及主要电解质变化发现：Ⅰ组（ｎ＝５，胞室注射速尿，２ｍｇ／ｋｇ）ＣＳＦ中６ｈ下降３．２ｍｍｏl／Ｌ，Ⅱ组（ｎ＝５，脑室注射等量生理盐水）ＣＳＦ中下降７．０ｍｍｏl／Ｌ，两组ＣＳＦ中的下降均伴有等量ＣＳＦ中［Ｃｌ￣－］的增加。结果说明速尿能抑制脉络丛上皮细胞对血浆Ｃl－的吸收和分泌，减少ＣＳＦ中和血浆Ｃl￣－的等量交换，提高ＣＳＦ对代谢性酸中毒的代偿能力，交换在ＣＳＦ酸碱调节中有重要作用。

he purpose of the present experiment was to study the effects of furosemide on cerebrospinal flu-id(CSF)acid-base regulation in acute metabolic acidosis.The acid-base variables of both arterial blood and CSF and prominent ions in two groups(n=5 each)of dogs were measured.One group was suNected to injec-tions of furosemide in ventricles of brain white,the other group(control)received the same volume of saline.CSF registered a 3.2 mmol/L drop in furosemide group and a 7.0 mmol/L drop in control group after 6h.It was found that the relationships between Cl￣- and concentrations were of particular significance in maintenance of electrolyte balance.The results suggest:Furosemide inhibits absorption and secretion of plasma Cl￣- by epithelial cells in choroid ptexus and exchanges;Furosemide can increase the com-pensation of CSF in acute metabolic acidosis,exchange plays an important role in regulation of CSF acid-base balance.