Mc9204对肾性高血压大鼠血压及肾脏血流动力学的影响

Effects of Mc9204 on blood Pressure and renal hemodynamics in re-nal hypertension rats

目的：观察并比较Ｍｃ９２０４（Ｃ＿（２０）Ｈ＿（２４）ＣｌＮＯ＿４，３７７）和硝苯地平（Ｎｉｆ）对肾性高血压大鼠血压及肾脏血流动力学的影响．方法：采用颈动脉插管测定血压，比色法测定肾血流量（ＲＢＦ），肾小球滤过率（ＧＦＲ）和尿Ｎａ￣＋．结果：ｉｖ连续输入Ｍｃ９２０４１，３，１０μｇ／（ｋｇ·ｍｉｎ）三个剂量，均能产生明显的降压作用，与空白对照组有显著差异（降压百分比分别为１７．７３±５．６３，３６．２１±９．００，５０．２３±５．１７ｕｓ４．２２±１．５１，５．００±３．０７，５．５０±３．０４，ｎ＝７，Ｐ＜０．０１）．并表现出剂量依赖性，Ｍｃ９２０４１μｇ／（ｋｇ·ｍｉｎ）使ＲＢＦ和ＧＦＲ同步增加，并出现排钠利尿作用．大剂量时，由于血压的过度降低，此作用被抵消．结论：Ｍｃ９２０４具有显著的降压及增加ＲＢＦ的作用，此作用明显大于Ｎｉｆ．

Objective:To compare the effects of Mc9204 and nifedipine(Nif)on blood pressure and renal hemodynamics in renal hypertensive rats.Methods:Carotid artery catheter was used to monitor mean blood pressure,and colorimetric assay was used for determination of renal blood flow(RBF),glornerular filtration rate(GFR)and urine Na￣+. Results:Results showed that Mc9204 iv,1,3,10 μg/(kg·min)could decrease blood pressure in concentration-dependent manner,and presented a significant difference compared with con-trol group(percentages of reduced blood pressure were 17.73±5.63,36.21±9.00,50.23±5.17 us 4.22±1.51,5.00±3.07,5.50±3.04 respectively,n=7,P<0.01).At the concentration of 1μg/(kg·min),it could simultaneously increase RBF and GFR,accompanied by excretion of urine Na￣+ and urine volume rise.But the effects were attenuated due to overreduced blood pressure at large doses:3,10μg/(kg·min).Con-clusion:Mc9204 is more effective than Nif in significantly decreasing blood pressure and increasing RBF.