甲氧西林金黄色葡萄球菌的耐药基因与耐药性关系

The relationship between resistant gene and resistance in MRSA

金黄色葡萄球菌对甲氧西林耐药的主要机制之一,是细菌染色体上的一段外源DNA(m ecA基因)编码产生对青霉素亲和力极低的青霉素结合蛋白2(PBP2a),m ecA基因在葡萄球菌属中分布广泛,它和细菌染色体上的一些辅助基因和调控基因的共同作用下影响细菌胞壁合成,使细胞表现出异质性耐药。而且M RSA是医院内和社区感染的重要致病菌,由于感染后治疗困难,因此成为国内外学者关注与研究的热点。本文主要从m ecA基因的来源、传播、结构功能、调控基因和辅助基因(fem或aux基因)等方面进行综述。

One of the resistance mechanisms of Staphylococcus aureus was the expression of mecA, an exogenous gene which encoded low affinity penicillin-binding protein 2a （PBP2a）. mecA gene, commonly occurred in MRSA, interfered the bacterial cell wall composition with some regulator and auxiliary genes, which led to bacterial heteraresistance heterogeneity. It is a major pathogen of hospitals and community infections. The article reviewed mecA gene in origin, transfer, structure, regulator and auxiliary gene, and so on.