摘要
以柔红霉素为原料,经八步反应制得盐酸伊达比星,总收率为24.2%。本法具有反应路线短,反应条件温和,操作简单等优点,适合工业化生产。
The modified semisynthetic process development of idarubicin was achieved in eight steps starting from daunorubicin. It featured with facile reaction conditions, convenient operation procedure and could be readily scale-up to mass producton.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2006年第3期181-183,共3页
Chinese Journal of Antibiotics
关键词
伊达比星
柔红霉索
半合成
工艺改进
Idarubicin
Daunorubicin
Semisynthetic method
Process development
