摘要
妊娠是一个复杂的生理过程,受到神经、免疫和内分泌的共同调节。作为半自体抗原的胎儿不被母体排斥是子宫局部免疫水平调节的结果。其中激素对辅助性淋巴细胞(Th)发生、分化的调节作用愈来愈受到重视。辅助T淋巴细胞能分化为不同的亚型(Th1和Th2),孕酮可促进Th2型细胞因子(IL-4,IL-5)的产生,有利于妊娠的正常发生;松弛肽促进Th1型细胞因子(IFN-γ)的产生,对妊娠有害。在母胎界面存在激素-细胞因子网络,淋巴细胞产生的细胞因子还能够影响其他细胞因子的产生。由Th2样细胞产生的,对胚泡着床具有非常重要作用的白血病抑制因子(LIF),其表达受Th1细胞诱导因子的下调,如IL-12,IFN-α,IFN-γ,受IL-4和孕酮(诱导T淋巴细胞向Th2细胞分化)的上调。激素通过调控淋巴细胞分泌的细胞因子来调控免疫系统,保持一个动态的平衡,有利于维持妊娠。
Pregnancy is modulated by nerve, immunity and endocrine system, and is a complex physiological process. The reason of embryo with a semiallogeneic graft having to be tolerated by the maternal immune system over the full gestational period is the regulation of immunoreaction in local uterus. The effect of hormone on lymphocytes is more and more get attention. Development of CD4^＋ helper T （Th） cells into type 1 （Th1） or type 2 （Th2） effectors, as characterized by their opposite pattern of cytokine production. Progesterone promotes the production of IL-4 and IL-5 by Th2, which are favorable to pregnancy. Whereas relaxin promotes the production of IFN-g by Th1 cells. Leukemia inhibitory factor （LIF）, essential for embryo implantation, is up-regulated by IL12, IFN-α, IFN-γ, IL-4 and progesterone. Hormone may contribute to the regulation of the immune homeostasis by the modulation the production of cytokines during pregnancy.
出处
《动物医学进展》
CSCD
2006年第1期24-27,共4页
Progress In Veterinary Medicine
关键词
细胞因子
激素
妊娠
cytokines
hormones
pregnancy
