弓形虫感染精神分裂症患者临床及血液流变学观察

Observation on the clinical and hemorrheological changes in schizophrenia patients infected with Toxoplasma gondii

目的了解弓形虫感染的精神分裂症患者在临床上和血液流变学指标上的变化,探讨弓形虫感染与精神分裂症的关系。方法采用酶联免疫吸附法(ELISA)检测145例精神分裂症患者的血清弓形虫抗体水平,并测定血液流变12项指标、评定BPRS、SAPS、SANS。然后,按弓形虫抗体阳性和阴性进行分组比较。结果精神分裂症患者弓形虫抗体阳性率为13．1％；两组患者的BPRS总分、SANS总分、SAPS总分差异均无显著(P>0．05),但BPRS中的激活性和敌对猜疑因子分阳性组显著高于阴性组(P<0．01和P<0．05)；弓形虫抗体阳性组患者呈高粘滞低脑血流量的血液流变学特点,红细胞压积、电泳时间、电脉率等两组间差异无显著性(P>0．05)。结论弓形虫抗体阳性和阴性患者存在某些类似的临床特点和血液流变学特性,但也各有其特点,揭示弓形虫感染可能与精神分裂症的发病有关。

Objective To observe the clinical differences and the changes of hemorheological indices in seropositive and seronegative antibodies to Toxoplasma gondii in schizophrenia patients so as to explore the relationship between Toxoplasma gondii infection and the episode of schizophrenia . Methods The serum antibodies to Toxoplasma gondii in 145 schizophrenia patients were tested with enzyme- linked immunosorbent assay （ELISA）. The 12 hemorheologieal indices and BPRS, SAPS, SANS were evaluated. The results obtained from ＇the two groups were compared. Results The rate of positive antibody to Toxoplasma gondii was 13.1% in sehzophrenia patients. There no significant difference in the total scores of BPRS, SAPS, SANS between the two groups was observed （ P 〉 0.05）. But the scores of irriation fator and hostility/suspiciousness factors were significantly higher in the seropositive group than that of the seronegative group. （P 〈 0.01 and P 〈 0.05）. The hemorheologieal eharacteristies in seropositive group showed a hyper viscosity and low cerebral flow. There the HCT, time and rate of electrophoresis showed no significant differences between the two groups （ P 〉 0.05）. Conclusion There are some similarly clinical and hemorheologieal characteristics in seropositire and seronegative schizophrenia patients in addition to differences in clinical and hernorheologieal characteristics in the two groups, indicating that Toxoplasma gondii infection may be associated with the occurrence of sehizhophrenia.