原发性青光眼不同区域多焦视觉诱发电位的研究(英文)

The comparison of mfVEP in normal eyes and glaucomatous eyes

目的:比较正常人和原发性青光眼患者不同分区的多焦视觉诱发电位(multifocalvisualevokedpoten-tial,mfVEP),评价mfVEP在青光眼诊断中的作用。方法:采用法国VisionMonitor多焦视觉电生理仪的二阶kernel技术检测21例32只正常对照眼、37例58只原发性青光眼的mfVEP,将青光眼mfVEP振幅均方根(rootmeansquare,RMS)及潜伏期与正常对照眼行不同分区的比较。结果:正常眼mfVEP的RMS值个体间变异大(变异系数CV=43.05%)。青光眼mfVEP的RMS值在上下半视野,鼻上、颞上、鼻下、颞下四个象限及各个环形分区均较正常对照眼小,且在0～10°环形区域及鼻上象限差异有显著性意义(P<0.05),二者各个区域的潜伏期无差异。结论:正常人mfVEP个体间变异性大;青光眼患者mfVEP振幅较正常人下降,且在中央区域及鼻上象限更为显著。

AIM： To test the ability of mulUfocal visual evoked potential （mfVEP） in the detecting of glaucoma by comparing the mfVEP recorded from normal subjects and glaucoma patients. METHODS： The mfVEP of 32 normal eyes （n=21） and of 58 eyes （n=37） with primary glaucoma were recorded with the Vision Monitor electrophysical apparatus by the second kernel analysis and to determine the correlation of the topographic location between them. RESULTS： There were significant variability （the coefficient of variation was 43.05%） in mfVEP RMS amplitude in the normal subjects; The RMS amplitude of eyes with glaucoma were smaller than that of the normal eyes and significanUy statisUcal difference were found in the relatively center （namely the 0°-10°ring zone） and in superior nasal quadrant （P〈0.05） while there were no significantly statistical differences of the latency time between them. CONCLUSION： The normal subjects have large individual variability of mfVEP responses. The RMS amplitude of the mfVEP of glaucomatous eyes descends, especially in center zone and superior nasal quadrant.