高度近视眼黄斑体积的分区测定

Analysis of macular volume in high myopia eyes using optical coherence tomography

目的:应用光学相干断层成像(OCT)技术研究高度近视眼黄斑部视网膜神经上皮层体积的变化。方法:将高度近视眼68例68眼和正常对照者59例59眼分为高度近视组和对照组,OCT测量黄斑中心凹最薄处神经上皮层厚度以及后极部视网膜地形图各个区域体积,比较两组结果的差异性。结果:高度近视眼组黄斑中心凹最薄处神经上皮层厚度145.7±20.2μm,正常对照组为151.9±26.7μm,两者差异无显著性(P=0.276)。高度近视眼组黄斑部视网膜神经上皮层体积为6.761±0.579mm3,正常对照组为7.262±0.508mm3,高度近视眼组黄斑体积明显小于正常组(P=0.006)。结论:OCT能够对黄斑部神经上皮层体积进行分区精确测量,可以作为研究高度近视眼后极部视网膜变化的手段之一。

AIM： To investigate the changes of the macular volume in high myopia eyes by optical coherence tomography （OCT）. METHODS：Eyes were categorized as high myopia group （68 eyes of 68 subjects） and normal group ± 59 eyes of 59 subjects）. Subjects received OCT analysis with the commercially available OCT3.0. The minimum macular thickness and the macular volume on the macular map were calculated automatically by OCT. The thickness and the volume in high myopia were compared with that in normal eye by independent-samples T-test. RESULTS：In high myopia group, the macular minimum thickness was 145.7± 20.2μm and the total macular volume on the macular map was 6.761± 0.579mm^3,the normal group was 151.9± 26.7μm and 7.262± 0.508mm^3 respectively. The macular volume in high myopia group was significantly smaller than that in the control group （P=0.006）. But no significant difference in the minimum thickness of neurosensory retina of the fovea was found between the two groups（P=0.276）. CONCLUSION.The macular volume can be measured precisely by OCT. OCT is an effective tool that can show the different pathological changes in high myopia eyes.