眼内新生血管与细胞因子

Intraocular neovascularization and cytokine

新生血管性眼病是眼科的难治性疾病和重要的致盲原因。新生血管的形成是许多细胞因子参与并相互作用的一个复杂过程,大量的研究表明新生血管形成与血管生成因子和血管生成抑制因子之间的失衡有关,促血管生成因子如生长因子、炎性细胞因子、瘦素等水平的提高和/或血管生成抑制因子如色素上皮细胞衍生因子、生长抑素等的减少将导致眼内新生血管的形成、发展,但其分子机制尚待阐明。

Ocular neovascularization is one of the most important clinical problems in ophthalmology and one of the most common causes of blindness. Angiogenesis is a course that a large group of cytokines participate and interact in complex way. Many studies suggest that neovascularization is caused by the unbalance between angiogenic stimulators, such as growth factor, inflammation cytokine, leptin and the angeogenic inhibitors including PEDF and smatostatin. The rise in inducers and/or drop in inhibitors also contribute to the ocular angiogenesis, but the molecular mechanism remains to be elucidated.