三氯乙烯致药疹样皮炎6例临床分析

Clinical Analysis of Six Cases with Drug Eruption-like Dermatitis Caused by Trichloroethylene

目的了解三氯乙烯引发的职业性皮肤病。方法对本院2003～2004年收治的6例职业性三氯乙烯致药疹样皮炎患者进行回顾分析。结果6例患者均为新工人，潜伏期平均25天，发病剧烈程度与所接触三氯乙烯浓度不成正比，无明显剂量-效应关系；3例皮损为重症多形红斑，另3例为剥脱性皮炎；其中4例伴严重肝损害。结论皮肤科医生应加强对三氯乙烯引发的药疹样皮炎的认识，避免误诊的发生。

Objective To investigate the occupational skin disease caused by trichloroethylene（TCE）. Methods Six patients with drug eruption-like dermatitis caused by TCE from 2003 to 2004 were analysed retrospectively. Results Six patients were new workers. The average latency period of TCE dermatitis was 25 d （Medium）. The occurrence of the dermatitis was not parallel to TCE exposure levels, without significant dose effect relationship. The major clinical manifestation included erythema multiforme major of 3 cases and exfoliative dermatitis with another 3. Four cases had liver dysfunction. Conclusion Dermatologist should have the knowledge of drug eruption-like dermatitis caused by TCE and avoid misdiagnosis.