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Erlotinib在肺癌应用中的相关分子和临床预后指标 被引量:2

Erlotinib in Lung Cancer - Molecular and Clinical Predictors of Outcome
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摘要 1文献类型 治疗。 2证据水平 1a。 3文献来源 Tsao MS, Sakurada A, Cutz JC, et al, Erlotinib in lung cancer-molecular and clinical predictors of outcome [J]. N Engl J Med, 2005,353: 133-134,
作者 张力 钟文昭
出处 《循证医学》 CSCD 2006年第1期10-13,共4页 The Journal of Evidence-Based Medicine
关键词 肺肿瘤 ERLOTINIB 表皮生长因子受体 预后 lung neoplasms Erlotinib epidermal growth factor receptor prognosis
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参考文献5

  • 1Lynch TJ,Bell DW,Sordella R,et al.Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib[J].N Engl J Med,2004,350:2129-2139.
  • 2Paez JG,Janne PA,Lee JC,et al.EGFR mutations in lung cancer:Correlation with clinical response to gefitinib therapy[J].Science,2004,304:1497-1500.
  • 3Pao W,Miller V,Zakowski M,et al.EGF receptor gene mutations are common in lung cancers from "never smokers"and are associated with sensitivity of tumors to gefitinib and erlotinib[J].Proc Natl Acad Sci USA,2004,101:13306-13311.
  • 4Cappuzzo F,Hirsch FR,Rossi E,et al.Epidermal growth factor receptor gene and protein and gefitinib sensitivity in nonsmall-cell lung cancer[J].J Natl Cancer Inst,2005,97:643-655.
  • 5Shepherd FA,Pereira JR,Ciuleanu T,et al.Erlotinib in previously treated non-small-cell lung cancer[J].N Engl J Med,2005,353:123-132.

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