益气活血化瘀中药对血管内皮功能的保护作用的实验研究

Experiment Study on Protection of Vascular Endothelial Function with TCM of Invigorating qi and activating blood and resolving stasis

目的:探讨益气活血化瘀中药对血瘀模型大鼠血管内皮功能的保护作用。方法:采用腹腔注射地塞米松的方法制备大鼠血瘀模型,观察益气活血化瘀中药对血浆内皮素(ET)、组织型纤溶酶源激活剂(tPA)及纤溶酶源激活物抑制剂(PAI)的影响。结果:益气活血化瘀中药可明显降低血瘀模型大鼠血浆内皮素(ET)及纤溶酶源激活物抑制剂(PAI)的水平(P<0.01),改善组织型纤溶酶源激活剂(tPA)的水平(P<0.01)。结论:益气活血化瘀中药对血管内皮功能有显著的保护作用。

Objective： To observe the protective effection of yiqihuoxuehuayu cornpand chinese medicine on vascular endothelial function in hypostasis model rats. Method： hypostasis model was induced by injecting dexamenthasone and observed the influence of yiqihuoxuehuayu cornpand chinese medicine on ET, tPA and PAl. Results： It can lower the level of ET and PAl obviously（ P〈 0.01 ）, at the same time, it can improve the level of tPA（ P 〈 0.01 ）. Conclusion： Yiqihuoxuehuayu compand chinese medicine can protect vascular endothelial function obviously.