摘要
用对硝基苯乙酮、乙二醇、苯乙腈、氢气、高氯酸为原料,经酮基保护、环化、催化加氢和消除反应合成出标题化合物。催化加氢的最佳反应条件为5-(2-甲基-1,3-二氧戊环)-3-苯基-1,2-苯异吡咯/H2的物质的量比为1∶3,Pd/C催化剂的含量为5%,室温催化加氢的时间为4h,Pd/C催化剂可以多次使用。对于ABP的合成,高氯酸/2-氨基-5-(2-甲基-1,3-二氧戊环)二苯甲酮物质的量比为4.0左右,反应温度为60℃。
5-Acetyl-2-aminobenzophenone（ABP） was synthesized by using p-nitroacetophenone, ethylene glycol, phenylacetonitrile, hydrogen, perchlorie acid as raw materials. The best reaction condition of hydrogenation was as follows： The mole ratio of reactants MDOPhBIX/H2=1：3 , the content of Pd/C=5%, the reaction time was 4h, the reaction temperature was at room temperature, Pd/C could be used repeatedly. The synthesis condition of ABP was as follows： the mole ratio of perohloric acid/OBP = 1： 4, the reaction temperature was 60℃.
出处
《化学试剂》
CAS
CSCD
北大核心
2006年第3期175-176,179,共3页
Chemical Reagents
基金
国家973资助项目(5130702002)
