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鼠角膜TRAIL mRNA表达与角膜移植排斥反应 被引量：1

Expression of TRAIL mRNA in mice cornea.
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摘要 目的观察正常鼠眼角膜组织中“肿瘤坏死因子相关凋亡诱导配体(TRAIL)的表达分布情况。方法采用RT-PCR技术和免疫组化技术检测TRAIL,定性、定位分析TRAIL在正常BALB/c鼠角膜组织中的表达。结果TRAIL mRNA在正常BALB/c鼠角膜组织中表达,免疫组织化学检测显示:角膜上皮层、内皮层强表达,间质层弱表达。结论TRAIL广泛存在于角膜组织中,有抑制或减轻角膜移植免疫排斥反应的作用,但其机制有待进一步深入研究。 Objective To investigate the expression of TRAIL in the normal cornea of mouse, Methods The corneal TRAIL in was BALB/c mouse meanned by RT-PCR and immunchistochemistry. Results BALB/c mouse cornea constitutively express TRAIL mRNA,Immunchistochemical analysis revealed TRAIL protein was constitutively expressed in endothelium and epithelium,and modest staining in the stroma. Conclusions TRAIL expressed extensivly on the cornea. It＇s function in the allograft rejection needs further study.
作者 黎小军 李丽 詹玉蕊 王雪琴
机构地区 兰州大学第一医院眼科 兰州大学医学院生化教研室
出处 《眼外伤职业眼病杂志》 北大核心 2006年第3期165-167,共3页 Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries
关键词 BALB/C鼠 角膜移植 TRAIL 表达 BALS/c mice kcratoplasty TRAIL expression
分类号 R779.65 [医药卫生—眼科]
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参考文献19

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二级参考文献28

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共引文献14

同被引文献39

  • 1宫华青,高华,谢立信,史伟云.穿透性角膜移植术后慢性失功移植片的超微结构观察[J].中华眼科杂志,2007,43(4):307-312. 被引量：14
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眼外伤职业眼病杂志
2006年 第3期

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