原发性肾病综合征患儿足量激素治疗前后血、尿白细胞介素-6检测的意义

Changes of Interleukin-6 in Serum and Urine in Children with Primary Nephrotic Syndrome and Their Clinical Significance

目的探讨原发性肾病综合征(PNS)患儿足量激素治疗前后血、尿白细胞介素-6(IL-6)水平变化的意义。方法初治PNS患儿38例,分别于足量激素治疗前和治疗8周后(或尿蛋白转阴2周后)用ELISA方法检测血、尿IL-6含量。比较激素敏感组和耐药组血、尿IL-6变化。结果激素治疗前,激素敏感组和耐药组血IL-6均较对照组显著升高(P均<0.01),两组比较无显著性差异(P均>0.05)。激素治疗前激素敏感组和耐药组尿IL-6均较对照组显著升高(P均<0.01),两组比较有显著性差异(P<0.01)。激素治疗8周后激素敏感组血、尿IL-6均降低,与对照组比较无显著差异(P>0.05),而耐药组血、尿IL-6水平无明显降低,与对照组比较仍有显著性差异(P<0.01)。结论血、尿IL-6可作为PNS患儿激素敏感性和预后估计的参考指标之一。

Objective To explore the clinical significance of the changes of interleukin-6 （IL-6） contents in serum and urine in children with primary nephrotic syndrome（PNS）. Methods The contents of IL-6 in serum and urine in 38 cars of PNS were examined by ELISA before and after treatment with prednisone 2 mg/（kg·d） for 8 weeks. Results Before the treatment with prednisone, the contents of IL- 6 in serum in steroid responsive group and steroid-resistant group were significantly higher than those in the normal controls（ P〈0.01）. There was no significant difference between the 2 groups（P 〉0.05）. In the steroid responsive group and steroid-resistant group,the levels of IL-6 in urine were significantly higher than those in the normal controls（P〈0.01）. There were significant differences the in 2 groups （ P〈0.01 ）. After the treatment with prednisone for 8 weeks, the contents of IL-6 in serum and urine in steroid-responsive group were significantly lower. There was no significant difference with the normal controls （P〉0.05）. The contents of IL-6 in steroid-resistant group in serum and urine had significant difference in the comparison with the normal controls（P〈0.01）. Conclusion The change of IL-6 is a referring index for judging the steroid sensitivity and estimating the prognosis of PNS.