肝癌自发性破裂机理的研究进展

Mechanism of Spontaneous Rupture of Hepatocellular Carcinoma

目的探讨肝癌自发性破裂的机理。方法采用文献回顾的方法,对肝癌自发性破裂患者的资料加以综述。结果肝癌自发性破裂的患者体内抗原抗体复合物积聚并沉积在小动脉壁弹力膜上,在其沉积处的小动脉壁存在血管受损现象。结论乙肝病毒感染所形成的抗原抗体复合物沉积在血管壁导致小动脉脆性病变,可能与肝癌自发性破裂出血有关。

Objective To study the mechanism of spontaneous rupture of hepatocellular carcinoma （HCC）. Methods Articles have been reviewed to find out the theory of spontaneous rupture of HCC. Results Researchful results suggested that the injury of small arteries was usually followed in patients of spontaneous rupture of HCC. In this review, the immune complex, which composed of hepatitis B virus e antigen, complement Clq and immunoglobulins, was found deposited in the elastic membrane of arteries. Likely as a result of immune complex deposition, vascular injury occurs mainly in the small arteries where the deposition of immune complex was present. The small arteries in which immune complex deposited are readily injuried and cause hemorrhage and rupture of HCC during vascular load increase. Conclusion We would conclude that immune complex deposition in vessel wall led to the small arteries injury may be the factor involved in the pathogenesis of spontaneous ruptured HCC.