聚-己内酯隔离膜防止大鼠术后腹腔粘连作用的研究

Prevention of Peritoneal Adhesion Formation with Biomaterial-Degradable Polycaprolactone Film

目的探索高分子生物降解材料在预防腹腔粘连中的作用。方法120只大鼠按编号法随机均分为对照组、乳胶隔离膜组和聚-己内酯(polycaprolactone,PCL)隔离膜组。对照组手术建立腹腔粘连动物模型,乳胶隔离膜组和PCL隔离膜组在该手术基础上,分别将两膜固定在腹膜创面上。3组动物分别于术后1、3、7及30 d不同时点各取10只大鼠开腹观察腹腔粘连情况。结果对照组全部发生腹腔粘连,乳胶隔离膜组及PCL隔离膜组粘连率明显减低,以后者更显著。结论PCL膜能被假单胞杆菌脂肪酶降解,避免异物刺激产生新的粘连,故此膜为首选。

Objective To investigate the effects of high molecular bio-degradable film on preventing peritoneal adhesion. Methods One hundred and twenty rats were divided into control group, non-bio-degradable film group and polycaprolactone （PCL） group. Animal models of peritoneal adhesion made by operations on rats serve as control group. In the study, non-bio-degradable film and bio-degradable, namely PCL films sensitive to pseudomonas enzyme, were put into the opening of peritoneum. The effect of the films on peritoneal adhesion was examined on 1, 3, 7 and 30 d after operation. Results Peritoneal adhesion was found in all the rats of control group and very low in PCL group and non-bio-degradable film group. Conclusion PCL film can effectively prevent the formation of postoperative peritoneal adhesion.