摘要
目的探讨中华眼镜蛇毒C组分(FC)对胶质瘤细胞株(U-251细胞株)的抑制作用。方法应用MTT法,观察NajaNajaAtraVenom(NNAV)FC对人胶质细胞瘤株U-251的细胞毒作用、量效关系等,并与vm-26对上述细胞的细胞毒作用进行比较。结果FC对人胶质瘤细胞有明显的抑制作用,其24h及48h的IC50分别为5.76μg/ml和7.19μg/ml,且呈良好的量效关系。结论FC能有效抑制胶质瘤细胞株的生长,抑制作用与浓度呈正相关,与卫萌相比较,FC是有效的、能抑制胶质瘤细胞生长的药物。
Objective To investigate the inhibition of fraction C （FC） from Naja Naja Atra Venom （NNAV） on U-251 glioma cell line. Methods MTT was involved in detecting the cytotoxic effects, dose-effect related rates of FC on human glioma cell line （U-251）, These effects were compared with VM-26 on the above mentioned cells. Results The proliferation of U-251 was obviously inhibited by FC in a dose dependent manner. The inhibitive effect of FC on U-251 was obvious, with the ICs0 5.76 ug/ml-7.19 ug/ml at 24 h and 48 h respectively. Conclusion FC can inhibit the proliferation of U-251.
出处
《解剖学研究》
CAS
2006年第1期23-25,共3页
Anatomy Research
基金
深圳市科技局计划(200404063)
