老年雌性和雄性大鼠学习记忆能力比较

Comparison of the abilities of learning and memory between aged female and male wistar rats

目的观察老年雌、雄性wistar大鼠的学习记忆能力的差异,进一步探索雌激素对学习记忆的影响。方法26只18月龄健康Wistar大鼠,其中雌性16只,雄性10只,在相同环境中饲养2个月后,用Morris水迷宫测试并分析其学习记忆能力的差异。结果在各时段老年雌性大鼠的逃避潜伏期均长于老年雄性大鼠,第5～9时段雌性大鼠的逃避潜伏期显著高于雄性大鼠(P<0.01),雌性大鼠的穿台次数显著低于雄性大鼠(P<0.05)。结论雌激素撤退在老年雌性大鼠学习记忆能力下降的中起到了主要作用。

Objective To observe the difference of learning and memory abilities between the aged female and male wistar rats, and to explore the impact of estrogen to the learning and memory. Methods 26 healthy Wistar rats of 18-month-old, 16 female and 10 male, were bred in same conditions for 2 months, then their abilities of learning and memory were detected and statistically analyzed. Results The average escape latencies of aged female rats were longer than that of male in each block, and in the 5th to 9th blocks there were significant statistical difference （P〈0.01）. The average number of female rats passing the platform was 3.75±2.11 times, which is significantly lower than that of male 6.4±3.98 times （P〈0.05）. Conclusion The estrogen withdraw plays a major role in the decrease ability of learning and memory aged female rats.