辣椒素受体研究进展

Advancement of vanilloid receptor 1

辣椒素受体(vanilloid receptor subtype1,VR1)是机体的一个重要的伤害性感受分子,除了参与中枢和外周水平疼痛的形成外,还参与了多种生理活动和病理过程。激活神经纤维末端的辣椒素受体,可调节外周血管的舒缩,影响血压;对缺血心肌起到保护作用;辣椒素受体还参与哮喘的发生,调节胃酸的分泌,促进胃肠蠕动。另外,激活辣椒素受体,还可抑制毛干的增殖,并介导肿瘤细胞的凋亡。本文主要就辣椒素受体近几年的研究情况作一简要综述。

Vanilloid receptor subtype 1 （VR1） is a central molecule of injury sense. VR1 plays an important role in pain generation at central nerve system level, or at peripheral level; further more, VR1 involves in many physiological actions and pathological processes. The activated VR1 at the terminus of nerve can regulate blood pressure by affecting peripheral blood vessel contraction or relaxation. Activated VR1 can protect myocardium fromischemic injury. VR1 is also involved in asthma, gastric secretion, and gastrointestinal motility. Besides, VR1 activation can inhibit hair shaft growth, and induce tumor cells apoptosis. The concise report reviewed the advancement of VR1 research in recent years.