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DNA甲基化与肿瘤诊断 被引量：1

DNA methylation and tumor disease
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摘要 DNA甲基化异常是人类肿瘤中常见的表观遗传变化之一,伴随着肿瘤的发生和发展,且该异常现象在肿瘤患者的外周循环血清、血浆和尿液等体液中都可检测到。因此,利用DNA甲基化分析技术检测体液中特定分子DNA甲基化水平是肿瘤早期诊断、病程监控和疗效评估的潜在手段,对临床肿瘤的诊治意义重大。 Abnormal methylation of DNA in certain genomic regions is a frequent epigenetic alteration that is involved in Human tumorigenesis and development. Various studies have shown that this aberrant DNA modification can be detected in body fluids of tumor patients, e. g. circulating blood, sputum, urine. So the evaluation of DNA methylation in these body fluids by methylaion detection methods can be utilized as a potential biomarker for early cancer detection and accurately clinical assess. This plays a significant role in cancer diagnosis and treatment.
作者 吴仲南 周向军 王永祥
机构地区 上海交通大学药学院分子药理学实验室
出处 《中国临床药理学与治疗学》 CAS CSCD 2006年第2期131-135,共5页 Chinese Journal of Clinical Pharmacology and Therapeutics
基金 上海市科委重大科技攻关项目资助课题(№04DZ19211)
关键词 DNA甲基化 二核苷酸胞嘧啶岛 表观遗传 DNA甲基转移酶 肿瘤诊断 DNA methylation CpG island epigenetics DNA methyl-transferase tumor diagnose
分类号 R730.49 [医药卫生—肿瘤]
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参考文献27

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同被引文献17

  • 1屠红,高海峰,傅士龙,陈颢.肿瘤患者循环DNA的定量研究[J].中华肿瘤杂志,2004,26(10):606-608. 被引量：8
  • 2今毅,谢文,余小萍,郑晖.乳腺癌患者肿瘤循环DNA的定量分析[J].第四军医大学学报,2007,28(11):1024-1026. 被引量：8
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中国临床药理学与治疗学
2006年 第2期

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