阿司匹林胃漂浮微球的制备

Preparation of aspirin floating oral delivery system

目的 制备阿司匹林胃内滞留漂浮微球。方法 以乙基纤维素为载体材料，采用乳化一溶剂扩散技术制备阿司匹林微球，通过正交试验优选制备工艺，并对微球的体外漂浮性能，包封率，栽药量，释放度等理化性能进行考察。结果 该法所制微球形态圆整，大小较均匀，粒径范围45～200μm，栽药量为32％，包封率为20．5％，体外12h漂浮率为37．6％。结论 本微球制备工艺较简单，重现性好。体外呈现较好的漂浮性能与缓释特性。

Objective To develop a floating oral delivery system of aspirin in hollow microspheres. Methods The aspirin microspheres were prepared by emulsion-solvent diffusion technique using ethyl cellulose as carrier polymer. The technology was optimized by orthogonal test. The physieochemieal properties of mierospheres such as buoyancy, drug loading, encapsulation efficiency and in vitro drug release were investigated, Results The prepared microspheres were spherical with a size distribution range between 45 and 200μm. The drug loading capacity and encapsulation efficiency was found to be 32% and 20, 5%, respectively, The floating rate after 12 hours was 37.6%. Conclusion He preparation technique of floating aspirin microspheres is simple and reproducible. The enhanced buoyancy and sustained in vitro release properties of the microspheres make them a potential candidate for floating drug dosage systems.