心肌缺血再灌注损伤的线粒体通透性转换机制被引量：7

Mitochondrial permeability transition during the myocardium ischemia/reperfusion injury

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摘要 A central mechanism leading to necrosis and apoptosis during cardiac ischemia/reperfusion is believed to be the mitochondrial permeability transition (MPT), due to opening of mitochondrial permeability transition pore (mPTP), a multiprotein complex formed at the contact site between the inner and outer mitochondrial membranes. MPT is important in the processes of cell damage and death. The regulation of the MPT plays a key role in the regulation of cardiac mitochondria injury, appears of a novel target and high interest in various therapeutic indications for cardioprotective. A central mechanism leading to necrosis and apoptosis during cardiac ischemia/reperfusion is believed to be the mitoehondrial permeability transition （MPT）, due to opening of mitochondrial permeability transition pore （mPTP）, a multiprotein complex formed at the contact site between the inner and outer mitochandrial membrancs. MPT is important in the proccsses of cell damage and death. The regulation of the MPT plays a key role in the regulation of cardiac mitocbondfia injury, appears of a novel target and high interest in various therapeutic indications for eardioproteetive.

作者李敬远王俊科曾因明

机构地区中国医科大学第一医院麻醉科江苏省麻醉医学研究所

出处《国际麻醉学与复苏杂志》 CAS 2006年第1期54-57,共4页 International Journal of Anesthesiology and Resuscitation

关键词心肌缺血再灌注损伤线粒体通透性转换机制线粒体功能障碍通透性转换孔研究发现 mitochondrial permeability transition myocardium ischemia/reperfusion injury

分类号 R541 [医药卫生—心血管疾病]

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1Crompton,M.The mitochondrial permeability transition pore and its role in cell death.Biochem J,1999,341:233 -249.
2Halestrap AP,Clarke SJ,Javadov SA.Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.Cardiovasc Res,2004,15:61(3):372-85.
3Halestrap AP,McStay GP,Clarke SJ.The permeability transition pore complex:another view.Biochimie,2002,84:153-166.
4Hausenloy DJ,Yellon DM.The mitochondrial permeability transition pore:its fundamental role in mediating cell death during ischaemia and reperfusion.J Mol Cell Cardiol,2003,35:339-341.
5Bernardi P,Petronilli V.The permeability transition pore as a mitochondrial calcium release channel:a critical appraisal.J Bioenerg Biomembr,1996,28:131-138.
6Srivastava R K,Sollott S J,Khan L,et al.Bcl-2 and Bcl -XL block thapsigargin -induced nitric oxide generation,c -J un NH2 -terminal kinase activity,and apoptosis.Mol Cell Biol,1999,19 (8):5659 -5674.
7Schild L,Keilhoff G,Augustin W,et al.Distinct Ca2 + thresholds determine cytochrome c release or permeability transition pore opening in brain mitochondria.FAS EB J,2001,15 (3):565 -567.
8Vieira HL,Belzacq AS,Haouzi D,et al.The adenine nucleotide translocator:a target of nitric oxide,peroxynitrite,and 42hydroxynonenal.Oncogene,2001,20 (32):4305 -4316.
9Vieira HL,Belzacq AS,Haouzi D,et al.The adenine nucleotide translocator:a target of nitric oxide,peroxynitrite,and 42hydroxynonenal.Oncogene,2001,20 (32):4305 -4 316.
10Joza N,Susin SA,Daugas E,et al.Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.Nature,2001,410:549-554.