前列腺素E_1联合多巴胺治疗冠心病心力衰竭的临床观察

Clinical Observation of the Effects on Cardiac Failure Caused by Coronary Heart Disease Treated with Prostaglandin E1 and Dopamine

目的:研究前列腺素E1(PGE1)联合多巴胺治疗冠心病心力衰竭的临床疗效。方法:将冠心病心力衰竭患者80例随机分为2组,2组均予常规抗心力衰竭治疗,治疗组在此基础上加用前列腺素E1和多巴胺,观察2组临床疗效。结果:治疗组总有效率92.5%,对照组总有效率75.0%,两组疗效比较有显著性差异(P<0.05)。两组间比较其左室射血分数(EF)、每分输出量(CO)、心指数(CI)、心脏舒张指标E峰/A峰比值(E/A)也有显著性差异(P<0.01)。结论:前列腺素E1联合多巴胺治疗冠心病心力衰竭患者疗效满意。

Objective： To observe the clinical effect of Prostaglandin E1 combined with dopamine on patients with cardiac failure caused by coronary heart disease （CHD）. Methods： 80 patients with heart failure caused by CHD were randomly divided into two groups and both treated with routine anti-cardiac failure method. The treatment group was given prostaglandin E1 and dopamine. The clinical curative effects of both groups were observed. Result： The total effective rate of treatment group was 92.5% and that of control group was 75.0%. The difference was significant between the two group （P 〈 0.05）. There were significant differences in the parameters, LVEF, CO, CI and E/A, between the treatment group and control group after therapy （P 〈 0.01）. Conclusion： The curative effect of Prostaglandin E1 combined with dopamine on patients with heart failure caused by CHD is satisfied.