含硅氨基甲酸酯衍生物的合成、结构及生物活性

Synthesis, Structure and Biological Activity of Novel Silicon-containing Carbamates

通过１－甲硫基亚乙基氨－甲基氨基甲酸酯与二氯亚砜反应，制得一系列新的含硅氨基甲酸酯衍生物．化合物结构经１￣ＨＮＭＲ、元素分析ＩＲ和ＭＳ确证，测定了化合物３ａ的晶体结构．生物测定结果表明，该类化合物对蚊子、粘虫、玉米螟等多种害虫具有优良的杀虫活性，且与母体灭多威相比，在哺乳动物安全性方面有显著提高．

A series of new silicon-containing carbamate derivatives 3 have been prepared from reaction of 1-methylthio-ethylideneamino-methyl carbamate (Methomyl) 1 with thionyl chloride. Their structures were confirmed by1 HNMR,elemental analysis,IR and MS. The crystal structure of compound 3a was determined by X-ray diffraction method.The bioassay results showed that compound 3 have a high insecticidal activity against mosquito,armyworm, European corn borer, flour beetle and cowpea aphid and a substantial improvement in acute mammalian safety toward male and female mice when compared to that of parent Methomyl.