头孢呋辛钠疗效和安全性再评价

Safety and efficacy re-evaluation of cefuroxime sodium

目的进一步评价头孢呋辛钠治疗细菌性感染的安全性、有效性及药物不良反应。方法开放试验,每次1.5 g,每日2次,静脉注射,重度患者每次3.0 g,每日2次。手术后预防细菌感染,每日1次,每次1.5 g,静脉注射。结果头孢呋辛钠治疗呼吸道感染痊愈率65.06%、有效率88.86%。其细菌总清除率为88.87%,药物不良反应发生率为4.5%。结论头孢呋辛钠治疗呼吸道感染、泌尿道感染、其他感染及手术后预防细菌感染疗效确切,药物不良反应少而轻。

Objective To evaluate the clinical efficacy and safty of cefuroxime sodium. Methods An open labeled multi-center clinical trial was conducted for the treatment of 715 patients with bacterial infections. Cefuroxime sodium as a trial drug was administrated 1.5 g doses for mild to moderate infections and preventive infections after operation and 3.0 g doses for severe infections. Both were twice a day by iv infusion. Results The results showed the clinical cure rates of respiratory tract infections was 65.06 %, respectively. The clinical effective rates of respiratory tract infections was 88.86 %, respectively. The bacterial clearance rates were 88.87 %. The adverse drug reaction rates were 5.6 %. Conclusions cefuroxime is a safe and effective drug in the treatment of infections of respiratory tract, urinary tract and other infections.