4,6,7,8-四氢-4,6-二芳基氧杂吖庚因[4,3-c]斯德酮顺反异构体的转化

Isomerization of cis-and trans-4,6-diaryl-4,6,7,8-tetrahydro[1,4] oxazepino[4,3-c] sydnone

用3-(3-苯基-3-羟基丙基)斯德酮和芳香醛反应合成了cis-和trans-4,6,7,8-四氢-4,6-二芳基氧杂吖庚因[4,3-c]斯德酮,这两种异构体在通常情况下都是稳定的,可以用柱层析进行分离提纯.在质子酸催化下,两种异构体均可以发生异构化,得到cis-和trans-异构体混合物.顺反式异构体的比例可以用1H NMR进行测定.

Both cis - and trans - 4,6 - diaryl - 4,6,7,8 - tetrahydro [ 1,4 ] oxazepino [ 4,3 - c ] sydnones prepared from the reaction of 3 - （3- phenyl- 3 -hydroxylpropyl） sydnone and aromatic aldehydes are stable isomers and can be isolated and purified by chromatography commonly, in the presence of protonic acid, cis -or trans - isomer can be isomerized to a mixture of cis - and trans - isomer. The chemical shift of H- 4 of cls - isomer is smaller than that of trans - isomer. The ratio of cis - and trans - isomer can be measured by ^1 H NMR.