摘要
用4,4-二烷硫基-3-烯-2-丁酮(1)作为无气味硫醇替代试剂在硫杂迈克尔加成反应中进行了研究.用浓盐酸做催化剂,将一系列α,β-不饱和酮(2)与1在无溶剂条件下混合发生反应,得到了相应的产率较高硫杂迈克尔加成产物(3),并对其反应机理进行了探讨.
4,4 - Bis(alkylthio)but- 3 - en- 2 - one 1 have been investigated as odorless thiol equivalents in thia-michael addition reaction. Promoted by concentrated hydrochloric acid, a range of α,β- unsaturated ketones 2 reacted with 1 under solvent - free conditions affording the corresponding thia- michael adducts 3 in high yields. Moreover, a mechanism for this thia- michael addition reaction is proposed.
出处
《东北师大学报(自然科学版)》
CAS
CSCD
北大核心
2006年第1期67-71,共5页
Journal of Northeast Normal University(Natural Science Edition)
基金
国家自然科学基金资助项目(20272008)
关键词
二硫缩烯酮
代硫醇试剂
硫杂迈克尔加成
Α
Β-不饱和酮
无溶剂
ketene - S, S - acetals
thiol equivalents
α,β- unsaturated ketones
thia - michael addition
solvent - free reaction