Ⅱ类反式激活蛋白与免疫应答

CIITA and Immune Response

MHCⅡ类分子在向CD4+T细胞提呈经过加工的抗原和诱发免疫反应中起重要作用。MHCⅡ类分子异常表达会引起裸淋巴细胞综合征等严重的免疫缺陷性疾病。目前已知CⅡTA是决定MHCⅡ类分子表达的主要调节因子。此外CⅡTA还影响着自身免疫性疾病、感染性疾病、肿瘤排斥、移植耐受等。因此,Ⅱ类反式激活蛋白作为影响诸多基因的单体蛋白,在干预MHCⅡ类分子提呈抗原途径上是理想的药物治疗靶点。

The MHC class Ⅱ （MHC- Ⅱ ） molecules play a pivotal role in the presenting peptides to the TCR of CD^4＋ T cells and induction of adaptive immune response. The class Ⅱ tmnsactivator （CⅡTA） is the master transcriptional regulator of genes involved in MHC-Ⅱ -restricted antigen presentation. The defect of CⅡTA can induce bare lymphocyte syndrome （BLS）, a hereditary severe combined immunodeficiency. Moreover, CⅡTA can impact autoimmune diseases, infectious diseases, tumor rejection, graft acceptance and perhaps even normal development. Therefore, as a single protein that affects a large family of genes, CⅡTA represents an ideal target for pharmacological intervention in the class Ⅱantigen presentation pathway.