抗原特异性细胞毒性T细胞体外扩增方法的研究近展

Recent Advance in Vitro Proliferation Methods of Antigen-specific CTLs

抗原特异性细胞毒性T细胞(cytoxicTlymphocytes,CTLs)在细胞免疫应答中起着重要的效应功能,从而在抗肿瘤和抗感染免疫中发挥着重要作用。由于受到各种因素的限制和影响,抗原特异性CTLs无法在体内有效地诱导和扩增,因此,通过体外诱导和扩增CTLs后再将此CTLs回输到体内是一个比较理想的方法,且具有重要的应用价值,如何高效激活和扩增抗原特异性CTLs是此法能否成功应用的关键。

Antigen-specific cytotoxic T lymphocytes （CTLs） have important effect on cell immune response, therefore play a crucial role in the anti-tumor and anti-infection immunity. However, CTLs can not be induced and proliferated effectively in vivo because of various suppressive fac- tors. An ideal way to overcome this problem is the adoptive transfer with CTLs which have high application value. The key point to carry out this way successfully is how to powerfully activate and expand antigen-specific CTLs