树突状细胞迁入淋巴组织的影响因素和信号通路

Factors that Regulated Dendritic Cells Migration to Lymph Nodes

树突状细胞(DCs)是功能强大的抗原递呈细胞,摄取抗原后,经淋巴管定向迁移进入淋巴结T细胞富集区,将抗原信息呈递给初始T细胞,从而引发一系列的特异性免疫应答。近年来发现DCs在体内该阶段迁移过程有一系列细胞因子和信号传导通路参与调控,其中CCR7及其配体CCL19和CCL21是最受关注的一组趋化因子。随着对调控机制研究的不断深入,发现MAPK信号途径和NFκB途径也参与迁移调控,另有一些因素则对其产生负调节作用。掌握调控DCs迁入淋巴组织的机制,有助于体外培养DCs为基础的过继性抗肿瘤免疫治疗技术的发展。

As antigen-presenting cells, dendritic cells （DCs） transport captured antigen from peripheral tissues to T cell zone of lymph nodes via lymphatic vessels. This migration is essential for antigen presentation that leads to priming of effector T cell responses. Here we review recent literature regarding factors and signals that regulate DC migration to lymph nodes via lymphatics, focusing on CCR7 activity, and other signaling events that regulate the development and execution of a migratory phenotype, such as MAP kinase and NF-κB pathway. Understanding the factors that govern migration will be benefit for exploring as DC-based cancer vaccines for immunotherapy in vivo.