肠道黏膜免疫

Intestinal Mucosal Immunity

肠道免疫系统由大量弥散分布在肠黏膜上皮内和固有层的免疫细胞和免疫分子、以及诸如peyer’spatches(PP)等肠相关性淋巴组织等组成。小肠PP结为肠黏膜免疫主要诱导部位,肠黏膜上皮和固有层为主要效应部位。B细胞、T细胞在PP结诱导后,分化、成熟,并移行到黏膜效应部位,发挥免疫效应功能。

The intestinal immune system consists of many immune cells and molecules scattered throughout the lamina propria and epithelium of the mucosa, as well as organised lymphatic tissues such as the peyer＇s patches. The peyer＇s patches which placed in the small intestine are the primary inductive sites. The main effector site is the lamina propria and epithelium of the mucosa, where mature T and B ceils migrate following induction in the peyer＇ s patches. Effector mechanisms that protect mucosal surfaces include CD8^＋ T cells and CD4^＋ T cells for cytokine production and IgA response.