阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血瘀证与血管紧张素转换酶基因多态性的关系

STUDY ON RELATIONSHIP BETWEEN POLYMORPHISM OF ANGIOTENSIN CONVERTING ENZYME GEGE AND STASIS SYNDROME IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA-HYPOPNEA SYNDROME

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)血瘀证与血管紧张素转换酶(ACE)基因多态性之间的关系。方法采用聚合酶链反应(PCR)技术检测65例OSAHS患者(35例血瘀证、30例非血瘀证)及20例正常人的ACE基因型。结果OSAHS组血瘀证患者ID基因型及Ⅰ等位基因频率明显高于非血瘀证和正常对照组(分别为70.96%和68%,(P<0.05)。含插入等位基因的患者快速动眼(REM)期睡眠较不含插入基因的患者明显增多(P<0.05),睡眠呼吸暂停低通气指数、最长呼吸暂停时间较DD基因型患者有增高趋势(P>0.05)。结论ACE基因Ⅰ等位基因和ID基因型可能与OSAHS及OSAHS高血压的发病有关,且可能为OSAHS血瘀证发病的易感基因。

Objective:To explore the relationship between the polymorphism of angiotensin converting enzyme (ACE) and blood stasis syndrome (BSS) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).Methods: The ACE gene type in 35 patients with OSAHA of BSS type, 30 OSAHS patients of non-BSS type and 20 healthy subjects (control) were determined by PCR assay.Results: Occurrence of ID genotype and I allelic genotype of ACE gene was higher in patients of BSS than that in patients of non-BSS and control .The REM of patients with allelic gene was obviously increased comparing with that patients without allelic gene (P<0.05). There were increased REM sleep, higher AHI, and longer apnea time in patients with DD gene type (P>0.05). Conclusion: The ACE I allelic gene type may be related to the occurrence of OSAHS and OSAHS hypertension ,and may be the susceptible gene of OSAHS in patients of OSAHS in patients of BSS type.