热硫化硅橡胶材料溶出液的紫外光吸收度与体外细胞增殖度的相关研究

Studies on correlation between cell relative growth rate and UV absorbance of the extract of medical heat-vulcanizing silicone rubbers

本研究对国内外4种医用热硫化硅橡胶进行了制品溶出液的紫外吸收度测定和体外细胞相对增殖度试验.结果发现,紫外吸收度对体外细胞对相增殖度显著相关.220nm紫外吸收度的测试可作为医用热硫化硅橡胶材料或制品安全性质量控制和管理检测的首选指标.

The chemical substance extraction test and cell relative growth rate test were car-ried out on the 4 kinds of medical heat vul-canizing silicone rubbers from China and foreign countries.It was found from the results that there was linear correlation between 220nm UV absorbance of the extracts and the cell rela-tive growth rate of the silicone rubbers. In the extraction test, the UV absorbance could be regarded as the most sensitive cri-teria to predict the safety of the medical heat vulcanizing silicone rubbers and prod-ucts.