降脂通脉方抗高脂血症及动脉粥样硬化的实验研究

Experimental Study on Effects of Jiangzhi Tongmai Fang on Inhibiting Hyperlipemia and Atherosclerosis

目的:探讨健脾消痰化瘀法中药复方降脂通脉方防治动脉粥样硬化的疗效与可能的机制。方法:给C57/BL-ApoE基因敲除小鼠喂饲胆固醇饲料90天,形成实验性高胆固醇血症和动脉粥样硬化斑块,同时中药组连续给复方中药喂养90天,实验结束后测量小鼠血脂,观察动脉壁的光镜改变。结果:降脂通脉方能抑制血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)的上升。结论:降脂通脉方能治疗实验性高脂血症,抑制动脉粥样硬化斑块的形成。

Objective： To observe the therapeutic effect and possible mechanism of Jiangzhi Tongmai Fang （JZTMF） on preventing and curing atherosclerosis with methods of invigorating the spleen, dispersing phlegm and dissolving blood stasis. Methods ： C57/BL-ApoE knock out mice were raised with cholesterol animal feeds for 90 days to form the experimental models of hypercholesterolemia and atherosclerotic plaque. At the same time the TCM group was given complex prescription of Chinese materia medica continuously for 90 days. The plasma Level of triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） were measured by the end of experiment. Light microscope was adopted to assess the degree of pathologic damage of arterial wall. Results ： Complex prescription of Chinese materia medica JZTMF with methods of invigorating the spleen, dispersing phlegm and dissolving blood stasis could inhibit the upgrade of plasma TC, LDL-C. Conclusion ： JZTMF could cure experimental hyperlipemia and inhibit the formation of atherosclerotic plaques.