甘精胰岛素在2型糖尿病强化治疗中的应用

Application of glargine in intensive therapy of type 2 diabetes mellitus

目的探讨睡前皮下注射甘精胰岛素与睡前注射中效胰岛素(NPH)对血糖控制较差糖尿病患者的疗效。方法将80例2型糖尿病患者分为睡前皮下注射甘精胰岛素组、睡前皮下注射NPH组,两组三餐前均皮下注射短效胰岛素,比较治疗后两组血糖达标时间、平均空腹血糖、血糖漂移、胰岛素用量、低血糖发生率。结果甘精胰岛素组在血糖达标时间、治疗后空腹血糖、日内血糖漂移、低血糖发生率方面均低于NPH组(P<0.05)。结论糖尿病患者应用甘精胰岛素联合短效胰岛素治疗,降糖效果显著,安全性高。

Objective, To investigate the clinical efficacy of glargine injected subcutaneously in bad-controlled diabetes mellitua. Methods： 80 patients with type 2 diabetes mellitus were divided into insulin glargine group （A） and NPH insulin group （B）. Comparation was made between them in terms of fasting blood glucose （FBG）, total daily insulin dose, duration of glycemic control, glycemic exeursion and hypoglycemic episodes. Results： There was a significant difference between the two groups （P〈0. 05）. FBG, duration of glycemic controlling, glyeemic excursion and hypoglycemie episode were lower in insulin glargine group than those in NPH group. Conclusions Insulin glargine had greater efficacy in lowering blood glucose, it is also much safer than NPH insulin.